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Davide Gentilini

Ricercatore
Sede:
DIPARTIMENTO DI SCIENZE DEL SISTEMA NERVOSO E DEL COMPORTAMENTO Via Bassi 21 Pavia Cascina Cravino
Telefono0382987993
E-maildavide.gentilini@unipv.it
Orari di ricevimentoLunedi 14.00 -16.00 oppure su appuntamento
InsegnamentiMetodologia Medico Scientifica 2 Laboratorio di Statistica

ATTIVITA’ DI RICERCA

Epidemiologia Genetica ed Epigenetica Statistica Medica Bioinformatica
Curriculumgentilini CV-2020
Pubblicazioni1. Gensous N, Garagnani P, Santoro A, Giuliani C, Ostan R, Fabbri C, Milazzo M, Gentilini D, di Blasio AM, Pietruszka B, Madej D, Bialecka-Debek A, Brzozowska A, Franceschi C, Bacalini MG. One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project. Geroscience. 2020 Jan 24. doi: 10.1007/s11357-019-00149-0. [Epub ahead of print] IF: 6.444 2. Polano M, Chierici M, Dal Bo M, Gentilini D, Di Cintio F, Baboci L, Gibbs DL, Furlanello C, Toffoli G. A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning. Cancers (Basel). 2019 Oct 15;11(10). pii: E1562. doi: 10.3390/cancers11101562. IF: 5.326 3. Gentilini D, Oliveri A, Fazia T, Pini A, Marelli S, Bernardinelli L, Di Blasio AM. NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis. PLoS One. 2019 Sep 19;14(9):e0222506. doi: 10.1371/journal.pone.0222506. eCollection 2019 4. Loi E, Moi L, Fadda A, Satta G, Zucca M, Sanna S, Amini Nia S, Cabras G, Padoan M, Magnani C, Miligi L, Piro S, Gentilini D, Ennas MG, Southey MC, Giles GG, Wong Doo N, Cocco P, Zavattari P. Methylation alteration of SHANK1 as a predictive, diagnostic and prognostic biomarker for chronic lymphocytic leukemia. Oncotarget. 2019 Aug 13;10(48):4987-5002. doi: 10.18632/oncotarget.27080. IF: 5.168 5. Cogliati F, Giorgini V, Masciadri M, Bonati MT, Marchi M, Cracco I, Gentilini D, Peron A, Savini MN, Spaccini L, Scelsa B, Maitz S, Veneselli E, Prato G, Pintaudi M, Moroni I, Vignoli A, Larizza L, Russo S. Pathogenic Variants in STXBP1 and in Genes for GABAa Receptor Subunities Cause Atypical Rett/Rett-like Phenotypes. Int J Mol Sci. 2019 Jul 24;20(15). pii: E3621. doi: 10.3390/ijms20153621. IF: 4.183 6. Colombo EA, Mutlu-Albayrak H, Shafeghati Y, Balasar M, Piard J, Gentilini D, Di Blasio AM, Gervasini C, Van Maldergem L, Larizza L. Phenotypic Overlap of Roberts and Baller-Gerold Syndromes in Two Patients With Craniosynostosis, Limb Reductions, and ESCO2 Mutations. Front Pediatr. 28;7:210. doi: 10.3389/fped.2019.00210. eCollection 2019. IF: 2.33 7. Verde, Federico, Tiloca, Cinzia, Morelli, Claudia, Doretti, Alberto, Poletti, Barbara, Maderna, Luca, Messina, Stefano, Gentilini , Davide, Fogh, Isabella, Ratti, Antonia, Silani, Vincenzo, Ticozzi, Nicola (2019). PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival. NEUROLOGICAL SCIENCES , ISSN: 1590-1874, doi: 10.1007/s10072-019-03834-2 IF: 2.285 8. Gnecchi-Ruscone, Guido Alberto, Sarno, Stefania, De Fanti, Sara, Gianvincenzo, Laura, Giuliani, Cristina, Boattini, Alessio, Bortolini, Eugenio, Di Corcia, Tullia, Sanchez Mellado, Cesar, Dàvila Francia, Taylor Jesus, Gentilini , Davide, Di Blasio, Anna Maria, Di Cosimo, Patrizia, Cilli, Elisabetta, Gonzalez-Martin, Antonio, Franceschi, Claudio, Franceschi, Zelda Alice, Rickards, Olga, Sazzini, Marco, Luiselli, Donata, Pettener, Davide (2019). Dissecting the Pre-Columbian genomic ancestry of Native Americans along the Andes-Amazonia divide. MOLECULAR BIOLOGY AND EVOLUTION , ISSN: 0737-4038, doi: 10.1093/molbev/msz066 IF: 14.797 9. Cilli, Elisabetta, Sarno, Stefania, Gnecchi Ruscone, Guido Alberto, Serventi, Patrizia, De Fanti, Sara, Delaini, Paolo, Ognibene, Paolo, Basello, Gian Pietro, Ravegnini, Gloria, Angelini, Sabrina, Ferri, Gianmarco, Gentilini , Davide, Di Blasio, Anna Maria, Pelotti, Susi, Pettener, Davide, Sazzini, Marco, Panaino, Antonio, Luiselli, Donata, Gruppioni, Giorgio. The genetic legacy of the Yaghnobis: A witness of an ancient Eurasian ancestry in the historically reshuffled central Asian gene pool. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY , vol. 168, p. 717-728, ISSN: 0002-9483 (2019) , doi: 10.1002/ajpa.23789 IF: 2.901 10. Rurali E, Perrucci GL, Gaetano R, Pini A, Moschetta D,Gentilini D, Nigro P, Pompilio G. Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients. Theranostics . 2019 Apr 12;9(8):2224-2234. doi: 10.7150/thno.30714 IF: 8.537 11. Schwartz, Peter J, Gentilini , Davide (2018). Can genetics predict risk for sudden cardiac death? The relentless search for the Holy Grail. EUROPEAN HEART JOURNAL , ISSN: 0195-668X, doi: 10.1093/eurheartj/ehy508 IF: 23.425 12. Persani, Luca, De Filippis, Tiziana, Colombo, Carla,Gentilini , Davide (2018). Genetic diagnosis of endocrine diseases by NGS: Novel scenarios and unpredictable results and risks.EUROPEAN JOURNAL OF ENDOCRINOLOGY , vol. 179, p. R111-R123, ISSN: 0804-4643, doi: 10.1530/EJE-18-0379 IF: 4.333 13. Ostan, R, Monti, D, MARI, DARIA, Arosio, B, Gentilini , D, Ferri, E, Passarino, G, De Rango, F, D’Aquila, P, Mariotti, S, Pasquali, R, Fanelli, F, Bucci, L, Franceschi, C, Vitale, G (2018). Heterogeneity of thyroid function and impact of peripheral thyroxine deiodination in centenarians and semi-supercentenarians: association with functional status and mortality. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES , ISSN: 1079-5006, doi: 10.1093/gerona/gly194 IF: 4.902 14. Mattioli, Elisabetta, Andrenacci, Davide, Garofalo, Cecilia, Prencipe, Sabino, Scotlandi, Katia, Remondini, Daniel, Gentilini , Davide, Di Blasio, Anna Maria, Valente, Sergio, Scarano, Emanuela, Cicchilitti, Lucia, Piaggio, Giulia, Mai, Antonello, Lattanzi, Giovanna (2018). Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. AGING CELL, ISSN: 1474-9718, doi: 10.1111/acel.12824 IF: 7.627 15. Giuliani, Cristina, Sazzini, Marco, Pirazzini, Chiara, Bacalini, Maria Giulia, Marasco, Elena, Ruscone, Guido Alberto Gnecchi, Fang, Fang, Sarno, Stefania, Gentilini , Davide, Di Blasio, Anna Maria, Crocco, Paolina, Passarino, Giuseppe, Mari, Daniela, Monti, Daniela, Nacmias, Benedetta, Sorbi, Sandro, Salvarani, Carlo, Catanoso, Mariagrazia, Pettener, Davide, Luiselli, Donata, Ukraintseva, Svetlana, Yashin, Anatoliy, Franceschi, Claudio, Garagnani, Paolo (2018). Impact of demography and population dynamics on the genetic architecture of human longevity. AGING, vol. 10, ISSN: 1945-4589, doi: 10.18632/aging.101515 IF: 5.179 16. Gentilini D, Somigliana E, Pagliardini L, Rabellotti E, Garagnani P, Bernardinelli L, Papaleo E, Candiani M, Di Blasio AM, Viganò P (2018). Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception. CLINICAL EPIGENETICS, vol. 10, p. 1-13, ISSN: 1868-7083, doi: 10.1186/s13148-018-0510-3 IF: 6.091 17. Gensous, Noémie, Franceschi, Claudio, Blomberg, Bonnie B., Pirazzini, Chiara, Ravaioli, Francesco, Gentilini , Davide, Di Blasio, Anna Maria, Garagnani, Paolo, Frasca, Daniela, Bacalini, Maria Giulia (2018). Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells. EXPERIMENTAL GERONTOLOGY, ISSN: 0531-5565, doi: 10.1016/j.exger.2018.01.019 IF: 3.224 18. Fazia Teresa, Pastorino Roberta, Notartomaso Serena, Busceti Carla, Imbriglio Tiziana, Cannella Milena, Gentilini Davide, Morani Gabriele, Ticca Anna, Bitti Pierpaolo, Berzuini Carlo, Dalmay Tamas, Battipaglia Giuseppe, Bernardinelli Luisa (2018). Acid Sensing Ion Channel 2: a new potential player in the pathophysiology of multiple sclerosis. EUROPEAN JOURNAL OF NEUROSCIENCE, ISSN: 0953-816X, doi: 10.1111/ejn.14302 IF: 2.832 19. Fadda, Antonio, Gentilini , Davide, Moi, Loredana, Barault, Ludovic, Leoni, Vera Piera, Sulas, Pia, Zorcolo, Luigi, Restivo, Angelo, Cabras, Francesco, Fortunato, Federica, Zavattari, Cesare, Varesco, Liliana, Gismondi, Viviana, De Miglio, Maria Rosaria, Scanu, Antonio Mario, Colombi, Federica, Lombardi, Pasquale, Sarotto, Ivana, Loi, Eleonora, Leone, Francesco, GIORDANO, SILVIA, Di Nicolantonio, Federica, Columbano, Amedeo, Zavattari, Patrizia (2018). Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor. INTERNATIONAL JOURNAL OF CANCER, ISSN: 0020-7136, doi: 10.1002/ijc.31380 IF: 7.36 20. Dicitore, Alessandra, Castiglioni, Sara, Saronni, Davide,Gentilini , Davide, Borghi, Maria Orietta, Stabile, Stefano, Vignali, Michele, Di Blasio, Anna Maria, Persani, Luca, Vitale, Giovanni (2018). Effects of human recombinant type I IFNs (IFN-a2b and IFN-ß1a) on growth and migration of primary endometrial stromal cells from women with deeply infiltrating endometriosis: A preliminary study. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, vol. 230, p. 192-198, ISSN: 0301-2115, doi: 10.1016/j.ejogrb.2018.10.004 IF: 1.809 21. Cassarino, Maria Francesca, Ambrogio, Alberto G., Cassarino, Andrea, Terreni, Maria Rosa, Gentilini , Davide, Sesta, Antonella, Cavagnini, Francesco, Losa, Marco, Pecori Giraldi, Francesca (2018). Gene expression profiling in human corticotroph tumours reveals distinct, neuroendocrine profiles. JOURNAL OF NEUROENDOCRINOLOGY, vol. 30, ISSN: 0953-8194, doi: 10.1111/jne.12628 IF: 3.392 22. Bacalini, Maria Giulia, Franceschi, Claudio, Gentilini , Davide, Ravaioli, Francesco, Zhou, Xiaoyuan, Remondini, Daniel, Pirazzini, Chiara, Giuliani, Cristina, Marasco, Elena, Gensous, Noémie, Di Blasio, Anna Maria, Ellis, Ewa, Gramignoli, Roberto, Castellani, Gastone, Capri, Miriam, Strom, Stephen, Nardini, Christine, Cescon, Matteo, Grazi, Gian Luca, Garagnani, Paolo (2018). Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, ISSN: 1079-5006, doi: 10.1093/gerona/gly048. IF: 4.902 23. Antonelli, Manila, Fadda, Antonio, Loi, Eleonora, Moi, Loredana, Zavattari, Cesare, Sulas, Pia, Gentilini , Davide, Cameli, Cinzia, Bacchelli, Elena, Badiali, Manuela, Arcella, Antonella, Morra, Isabella, Giangaspero, Felice, Zavattari, Patrizia (2018). Integrated DNA methylation analysis identifies topographical and tumoral biomarkers in pilocytic astrocytomas. ONCOTARGET, vol. 9, p. 13807-13821, ISSN: 1949-2553, doi: 10.18632/oncotarget.24480IF: 5.168 24. Mayosi, Bongani M., Fish, Maryam, Shaboodien, Gasnat, Mastantuono, Elisa, Kraus, Sarah, Wieland, Thomas, Kotta, Maria-Christina, Chin, Ashley, Laing, Nakita, Ntusi, Ntobeko B. A., Chong, Michael, Horsfall, Christopher, Pimstone, Simon N., Gentilini , Davide, Parati, Gianfranco, Strom, Tim-Matthias, Meitinger, Thomas, Pare, Guillaume, Schwartz, Peter J., Crotti, Lia (2017). Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy. CIRCULATION, CARDIOVASCULAR GENETICS, vol. 10, ISSN: 1942-325X, doi: 10.1161/CIRCGENETICS.116.001605 IF: 5.664 25. Gnecchi-Ruscone, Guido A., Jeong, Choongwon, De Fanti, Sara, Sarno, Stefania, Trancucci, Michela, Gentilini , Davide, Di Blasio, Anna M., Sherpa, Mingma G., Sherpa, Phurba T., Marinelli, Giorgio, Di Marcello, Marco, Natali, Luca, Peluzzi, Davide, Pettener, Davide, Di Rienzo, Anna, Luiselli, Donata, Sazzini, Marco (2017). The genomic landscape of Nepalese Tibeto-Burmans reveals new insights into the recent peopling of Southern Himalayas. SCIENTIFIC REPORTS, vol. 7, ISSN: 2045-2322, doi: 10.1038/s41598-017-15862-z IF: 4.122 26. Gentilini , Davide, Scala, Stefania, Gaudenzi, Germano, Garagnani, Paolo, Capri, Miriam, Cescon, Matteo, Grazi, Gian Luca, Bacalini, Maria Giulia, Pisoni, Serena, Dicitore, Alessandra, Circelli, Luisa, Santagata, Sara, IZZO, FRANCESCO, Di Blasio, Anna Maria, Persani, Luca, Franceschi, Claudio, Vitale, Giovanni (2017). Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach. ONCOTARGET, vol. 8, p. 41890-41902, ISSN: 1949-2553, doi: 10.18632/oncotarget.17462 IF: 5.168 27. G. Vitale, A. Dicitore, D. Pepe, D. Gentilini , E.S. Grassi, M.O. Borghi, G. Gelmini, M.C. Cantone, G. Gaudenzi, G. Misso, A.M. Di Blasio, L.J. Hofland, M. Caraglia, L. Persani (2017). Synergistic activity of everolimus and 5-aza-2’-deoxycytidine in medullary thyroid carcinoma cell lines. MOLECULAR ONCOLOGY, vol. 11, p. 1007-1022, ISSN: 1574-7891, doi: 10.1002/1878-0261.12070 IF: 5.264 28. Fazia, Teresa, Pastorino, Roberta, Foco, Luisa, Han, Lide, Abney, Mark, Beecham, Ashley, Hadjixenofontos, Athena, Guo, Hui,Gentilini , Davide, Papachristou, Charalampos, Bitti, Pier Paolo, Ticca, Anna, Berzuini, Carlo, McCauley, Jacob L, Bernardinelli, Luisa (2017). Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci. MULTIPLE SCLEROSIS, ISSN: 1352-4585, doi: 10.1177/1352458517732841 IF: 5.28 29. Durso, Danielle Fernandes, Bacalini, Maria Giulia, Sala, Claudia, Pirazzini, Chiara, Marasco, Elena, Bonafé, Massimiliano, do Valle, Ítalo Faria, Gentilini , Davide, Castellani, Gastone, Faria, Ana Maria Caetano, Franceschi, Claudio, Garagnani, Paolo, Nardini, Christine (2017). Acceleration of leukocytes’ epigenetic age as an early tumorand sex-specific marker of breast and colorectal cancer. ONCOTARGET, vol. 8, p. 23237-23245, ISSN: 1949-2553, doi: 10.18632/oncotarget.15573 IF: 5.168 30. De Filippis, Tiziana, Gelmini, Giulia, Paraboschi, Elvezia, Vigone, Maria Cristina, Di Frenna, Marianna, Marelli, Federica, Bonomi, Marco, Cassio, Alessandra, Larizza, Daniela, Moro, Mirella, Radetti, Giorgio, Salerno, Mariacarolina, Ardissino, Diego, Weber, Giovanna,Gentilini , Davide, Guizzardi, Fabiana, Duga, Stefano, Persani, Luca (2017). A frequent oligogenic involvement in congenital hypothyroidism. HUMAN MOLECULAR GENETICS ONLINE , vol.
CollaborazioniIstituto Auxologico Italiano